Sometimes I Feel Like a Piece of Bologna

Thursday, January 10, 2008

Alzheimer's Reversal

According to an article called “Rapid cognitive improvement in Alzheimer’s disease following perispinal etanercept administration” in the Journal of Neuroinflammation, patients receiving an injection of an anti-TNF therapeutic called etanercept showed improvement in Alzheimer’s disease within minutes of administration of the therapeutic molecule.

The study shows that a soluble protein known as tumor necrosis factor-alpha (TNF), which normally regulates transmission of neural impulses in the brain, interferes with regulation when it is present at elevated levels. The brains and cerebrospinal fluid of Alzheimer's patients show elevated levels of this cytokine.

Injection of etanercept shows improvement within minutes. Etanercept (trade name Enbrel) binds and inactivates excess TNF. Etanercept is FDA approved to treat a number of immune-mediated disorders and is used off label in the study.

The study was authored by Edward Tobinick M.D., assistant clinical professor of medicine at UCLA and director of the Institute for Neurological Research, with coauthor Hyman Gross, M.D., clinical professor of neurology at USC.


3 comment(s):

Thanks for highlighting this, Pat. Peer-mediated scientific journals crank out bone-dry prose. It's really easy not to notice a study like this one that may point the way toward treatment that might change everything for Alzheimer's patients and their families.


By Blogger Pete, at 7:02 AM  

Has anyone ever dealt with someone who is faking Alzheimer's? That's the situation I'm in now. I'm new to the blogging world, but have recently set up a blog for sandwich generation members to vent their frustrations. The web address is Feel free to vent your frustration.

By Anonymous Kathy, at 2:03 PM  

A friend, who' wife has Alzheimer's, tried this treatment out of TOTAL Desperation. After two injections and almost $10,000; it did NOT work. Of course there are no guarantees and there was no offer to refund a portion of his money. During the "screening process" he was reassured that they had witnessed "miraculous results" with patients regaining up to 30% - 40% of their memories and ability to function. My friend came away with the impression that the main motivation of this California practice was financial gain and preying on Alzheimer's victims and their families. They should be investigated by the appropriate authorities !!

By Anonymous Rick, at 9:57 PM  

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